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1

CD4+ T Cells Rely on a Cytokine Gradient to Control Intracellular Pathogens beyond Sites of Antigen Presentation

Müller, Andreas J., Filipe-Santos, Orchidée, Eberl, Gerard, Aebischer, Toni, Späth, Gerald F., Bousso, Philippe

Journal:

Year:

2012

Language:

english

File:

PDF, 1.52 MB

english, 2012

2

Photoconvertible Pathogen Labeling Reveals Nitric Oxide Control of Leishmania major Infection In Vivo via Dampening of Parasite Metabolism

Müller, Andreas J., Aeschlimann, Salome, Olekhnovitch, Romain, Dacher, Mariko, Späth, Gerald F., Bousso, Philippe

Journal:

Cell Host & Microbe

Year:

2013

Language:

english

File:

PDF, 2.90 MB

english, 2013

3

Hepatocyte Nuclear Factor 4 Provokes Expression of Epithelial Marker Genes, Acting As a Morphogen in Dedifferentiated Hepatoma Cells

Gerald F. Späth and Mary C. Weiss

Journal:

The Journal of Cell Biology

Year:

1998

Language:

english

File:

PDF, 3.84 MB

english, 1998

4

Exploration of the imidazo[1,2-b]pyridazine scaffold as a protein kinase inhibitor

Bendjeddou, Lyamin Z., Loaëc, Nadège, Villiers, Benoît, Prina, Eric, Späth, Gerald, Galons, Hervé, Meijer, Laurent, Oumata, Nassima

Journal:

European Journal of Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 909 KB

english, 2016

5

Old World cutaneous leishmaniasis challenges in Morocco, Algeria, Tunisia and Iran (MATI): a collaborative attempt to combat the disease

Bahrami, Fariborz, Späth, Gerald F., Rafati, Sima

Journal:

Expert Review of Vaccines

Year:

2017

Language:

english

File:

PDF, 530 KB

english, 2017

6

Adaptation of a 2D in-gel kinase assay to trace phosphotransferase activities in the human pathogen Leishmania donovani

Dirk Schmidt-Arras, Olivier Leclercq, Pier Federico Gherardini, Manuela Helmer-Citterich, Wolfgang Faigle, Damarys Loew, Gerald F. Späth

Journal:

Journal of Proteomics

Year:

2011

Language:

english

File:

PDF, 711 KB

english, 2011

7

Networking theLeishmaniaresearch community for the development of novel anti-leishmanial intervention strategies

Gerald F Späth

Journal:

BMC Proceedings

Year:

2011

Language:

english

File:

PDF, 173 KB

english, 2011

8

Phosphoproteomic analysis of Leishmania donovani pro- and amastigote stages

Miguel A. Morales, Reiko Watanabe, Christine Laurent, Pascal Lenormand, Jean-Claude Rousselle, Abdelkader Namane, Gerald F. Späth

Journal:

Year:

2008

Language:

english

File:

PDF, 510 KB

english, 2008

9

The flagellum–mitogen-activated protein kinase connection in Trypanosomatids: a key sensory role in parasite signalling and development?

Brice Rotureau, Miguel A. Morales, Philippe Bastin, Gerald F. Späth

Journal:

Cellular Microbiology

Year:

2009

Language:

english

File:

PDF, 178 KB

english, 2009

10

Quantitative proteome profiling informs on phenotypic traits that adapt Leishmania donovani for axenic and intracellular proliferation

Pascale Pescher, Thierry Blisnick, Philippe Bastin, Gerald F. Späth

Journal:

Cellular Microbiology

Year:

2011

Language:

english

File:

PDF, 1.19 MB

english, 2011

11

A Lipophosphoglycan-Independent Method for Isolation of Infective Leishmania Metacyclic Promastigotes by Density Gradient Centrifugation

Gerald F. Späth, Stephen M. Beverley

Journal:

Experimental Parasitology

Year:

2001

Language:

english

File:

PDF, 171 KB

english, 2001

12

Leishmania major intracellular survival is not altered in SHP-1 deficient mev or CD45−/− mice

Gerald F. Späth, Mary Ann McDowell, Stephen M. Beverley

Journal:

Experimental Parasitology

Year:

2008

Language:

english

File:

PDF, 403 KB

english, 2008

13

Over-expression of Leishmania major MAP kinases reveals stage-specific induction of phosphotransferase activity

Miguel A. Morales, Olivier Renaud, Wolfgang Faigle, Spencer L. Shorte, Gerald F. Späth

Journal:

International Journal for Parasitology

Year:

2007

Language:

english

File:

PDF, 738 KB

english, 2007

14

Exoerythrocytic development of Plasmodium gallinaceum in the White Leghorn chicken

Ute Frevert, Gerald F. Späth, Herman Yee

Journal:

International Journal for Parasitology

Year:

2008

Language:

english

File:

PDF, 3.69 MB

english, 2008

15

Collaborative actions in anti-trypanosomatid chemotherapy with partners from disease endemic areas

Jean-Claude Dujardin, Dolores González-Pacanowska, Simon L. Croft, Ole F. Olesen, Gerald F. Späth

Journal:

Trends in Parasitology

Year:

2010

Language:

english

File:

PDF, 634 KB

english, 2010

16

Is lipophosphoglycan a virulence factor? A surprising diversity between Leishmania species

Salvatore J Turco, Gerald F Späth, Stephen M Beverley

Journal:

Trends in Parasitology

Year:

2001

Language:

english

File:

PDF, 70 KB

english, 2001

17

PhosTryp: a phosphorylation site predictor specific for parasitic protozoa of the family trypanosomatidae

Antonio Palmeri, Pier Federico Gherardini, Polina Tsigankov, Gabriele Ausiello, Gerald F Späth, Dan Zilberstein, Manuela Helmer-Citterich

Journal:

Year:

2011

Language:

english

File:

PDF, 309 KB

english, 2011

18

A Dynamic Map of Antigen Recognition by CD4 T Cells at the Site of Leishmania major Infection

Orchidée Filipe-Santos, Pascale Pescher, Béatrice Breart, Christoph Lippuner, Toni Aebischer, Nicolas Glaichenhaus, Gerald F. Späth, Philippe Bousso

Journal:

Cell Host & Microbe

Year:

2009

Language:

english

File:

PDF, 2.06 MB

english, 2009

19

Imaging Host Cell-Leishmania Interaction Dynamics Implicates Parasite Motility, Lysosome Recruitment, and Host Cell Wounding in the Infection Process

Claire-Lise Forestier, Christophe Machu, Celine Loussert, Pascale Pescher, Gerald F. Späth

Journal:

Cell Host & Microbe

Year:

2011

Language:

english

File:

PDF, 1.65 MB

english, 2011

20

The Crystal Structure of the MAP Kinase LmaMPK10 from Leishmania Major Reveals Parasite-Specific Features and Regulatory Mechanisms

Sofía Horjales, Dirk Schmidt-Arras, Ramiro Rodriguez Limardo, Olivier Leclercq, Gonzalo Obal, Eric Prina, Adrian G. Turjanski, Gerald F. Späth, Alejandro Buschiazzo

Journal:

Year:

2012

Language:

english

File:

PDF, 3.45 MB

english, 2012

21

Phosphoproteomic Analysis of Differentiating Leishmania Parasites Reveals a Unique Stage-Specific Phosphorylation Motif

Tsigankov, Polina, Gherardini, Pier Federico, Helmer-Citterich, Manuela, Späth, Gerald F., Zilberstein, Dan

Journal:

Journal of Proteome Research

Year:

2013

Language:

english

File:

PDF, 2.65 MB

english, 2013

22

Protein Phosphorylation in Parasites || Trypanosomatid Cell Division Kinases

Doerig, Christian, Späth, Gerald, Wiese, Martin

Year:

2013

Language:

english

File:

PDF, 314 KB

english, 2013

23

Protein Phosphorylation in Parasites || Selective Inhibition of Parasite Protein Kinases

Doerig, Christian, Späth, Gerald, Wiese, Martin

Year:

2013

Language:

english

File:

PDF, 779 KB

english, 2013

24

Protein Phosphorylation in Parasites || Kinase Inhibitors Among Hits from Malaria Cellular Screens

Doerig, Christian, Späth, Gerald, Wiese, Martin

Year:

2013

Language:

english

File:

PDF, 897 KB

english, 2013

25

Protein Phosphorylation in Parasites || Hijacking of Host Cell Signaling by Theileria

Doerig, Christian, Späth, Gerald, Wiese, Martin

Year:

2013

Language:

english

File:

PDF, 293 KB

english, 2013

26

Protein Phosphorylation in Parasites || Kinetoplastid AGC Kinases

Doerig, Christian, Späth, Gerald, Wiese, Martin

Year:

2013

Language:

english

File:

PDF, 888 KB

english, 2013

27

Protein Phosphorylation in Parasites || Macrophage Kinases in Leishmaniasis

Doerig, Christian, Späth, Gerald, Wiese, Martin

Year:

2013

Language:

english

File:

PDF, 607 KB

english, 2013

28

Protein Phosphorylation in Parasites || Protein Kinases of the Parasitic Protist Entamoeba histolytica

Doerig, Christian, Späth, Gerald, Wiese, Martin

Year:

2013

Language:

english

File:

PDF, 843 KB

english, 2013

29

Protein Phosphorylation in Parasites || The Role of Host- and Parasite-Encoded Kinases in Toxoplasma -Host Interactions

Doerig, Christian, Späth, Gerald, Wiese, Martin

Year:

2013

Language:

english

File:

PDF, 705 KB

english, 2013

30

Protein Phosphorylation in Parasites || Protein Kinases as Suitable Targets for Combating Eimeria spp

Doerig, Christian, Späth, Gerald, Wiese, Martin

Year:

2013

Language:

english

File:

PDF, 1.48 MB

english, 2013

31

Protein Phosphorylation in Parasites || Trypanosomatid Phosphoproteomics

Doerig, Christian, Späth, Gerald, Wiese, Martin

Year:

2013

Language:

english

File:

PDF, 219 KB

english, 2013

32

Protein Phosphorylation in Parasites || Collaborative Drug Design of Plasmodium Kinase Inhibitors

Doerig, Christian, Späth, Gerald, Wiese, Martin

Year:

2013

Language:

english

File:

PDF, 1.20 MB

english, 2013

33

Protein Phosphorylation in Parasites || Protein Kinases as Drug Targets in the Treatment of Alveolar Echinococcosis

Doerig, Christian, Späth, Gerald, Wiese, Martin

Year:

2013

Language:

english

File:

PDF, 385 KB

english, 2013

34

Protein Phosphorylation in Parasites || Plasmodium eIF2α Kinases

Doerig, Christian, Späth, Gerald, Wiese, Martin

Year:

2013

Language:

english

File:

PDF, 260 KB

english, 2013

35

Protein Phosphorylation in Parasites || Receptor Tyrosine Kinase Signaling and Drug Targeting in Schistosomes

Doerig, Christian, Späth, Gerald, Wiese, Martin

Year:

2013

Language:

english

File:

PDF, 747 KB

english, 2013

36

Protein Phosphorylation in Parasites || Phosphatomes of Unicellular Eukaryotic Parasites

Doerig, Christian, Späth, Gerald, Wiese, Martin

Year:

2013

Language:

english

File:

PDF, 788 KB

english, 2013

37

Protein Phosphorylation in Parasites || Protein Phosphatases in Trypanosome Growth and Development

Doerig, Christian, Späth, Gerald, Wiese, Martin

Year:

2013

Language:

english

File:

PDF, 420 KB

english, 2013

38

Probing druggability and biological function of essential proteins in L eishmania combining facilitated null mutant and plasmid shuffle analyses

Dacher, Mariko, Morales, Miguel A., Pescher, Pascale, Leclercq, Olivier, Rachidi, Najma, Prina, Eric, Cayla, Mathieu, Descoteaux, Albert, Späth, Gerald F.

Journal:

Molecular Microbiology

Year:

2014

Language:

english

File:

PDF, 4.62 MB

english, 2014

39

Enrichment of Leishmania donovani ATP-binding proteins using a staurosporine capture compound

Leclercq, Olivier, Bartho, Kathrin, Duelsner, Erik, von Kleist, Lisa, Gherardini, Pier Federico, Palmeri, Antonio, Helmer-Citterich, Manuela, Baumgart, Sabine, Späth, Gerald F.

Journal:

Journal of Proteomics

Year:

2013

Language:

english

File:

PDF, 800 KB

english, 2013

40

Simultaneous multi-parametric analysis of Leishmania and of its hosting mammal cells: A high content imaging-based method enabling sound drug discovery process

Forestier, Claire-Lise, Späth, Gerald Frank, Prina, Eric, Dasari, Sreekanth

Journal:

Microbial Pathogenesis

Year:

2014

Language:

english

File:

PDF, 915 KB

english, 2014

41

Probing the dynamic nature of signalling pathways by IMAC and SELDI-tof MS

Foucher, Aude L., Späth, Gerald F., Pemberton, Iain K.

Journal:

Archives of Physiology and Biochemistry

Year:

2010

Language:

english

File:

PDF, 1.29 MB

english, 2010

42

Phosphoproteomic analysis of wild-type and antimony-resistant Leishmania braziliensis lines by 2D-DIGE technology

Moreira, Douglas de Souza, Pescher, Pascale, Laurent, Christine, Lenormand, Pascal, Späth, Gerald F., Murta, Silvane M. F.

Journal:

Year:

2015

Language:

english

File:

PDF, 2.14 MB

english, 2015

43

Les leishmanioses vues au travers du réseau international des Instituts Pasteur

Louzir, Hechmi, Aoun, Karim, Späth, Gerald F., Laouini, Dhafer, Prina, Eric, Victoir, Kathleen, Bouratbine, Aïda

Journal:

médecine/sciences

Year:

2013

Language:

french

File:

PDF, 2.22 MB

french, 2013

44

High Content Analysis of Primary Macrophages Hosting Proliferating Leishmania Amastigotes: Application to Anti-leishmanial Drug Discovery

Aulner, Nathalie, Danckaert, Anne, Rouault-Hardoin, Eline, Desrivot, Julie, Helynck, Olivier, Commere, Pierre-Henri, Munier-Lehmann, Hélène, Späth, Gerald F., Shorte, Spencer L., Milon, Geneviève, Pri

Journal:

PLoS Neglected Tropical Diseases

Year:

2013

Language:

english

File:

PDF, 5.47 MB

english, 2013

45

A Novel Role for Stat1 in Phagosome Acidification and Natural Host Resistance to Intracellular Infection by Leishmania major

Späth, Gerald F., Schlesinger, Paul, Schreiber, Robert, Beverley, Stephen M., Mansfield, John M.

Journal:

Year:

2009

Language:

english

File:

PDF, 539 KB

english, 2009

46

Transgenic Analysis of the Leishmania MAP Kinase MPK10 Reveals an Auto-inhibitory Mechanism Crucial for Stage-Regulated Activity and Parasite Viability

Cayla, Mathieu, Rachidi, Najma, Leclercq, Olivier, Schmidt-Arras, Dirk, Rosenqvist, Heidi, Wiese, Martin, Späth, Gerald F., Jaffe, Charles L.

Journal:

Year:

2014

Language:

english

File:

PDF, 4.42 MB

english, 2014

47

A touch of Zen: post-translational regulation of the L eishmania stress response

Späth, Gerald F., Drini, Sima, Rachidi, Najma

Journal:

Cellular Microbiology

Year:

2015

Language:

english

File:

PDF, 274 KB

english, 2015

48

Cross reactivity of S. aureus to murine cytokine assays: A source of discrepancy

Javed, Numan, Xue, Guang, Lu, Ailing, Xing, Yue, Iwakura, Yoichiro, Xiao, Hui, Lecoeur, Hervé, Späth, Gerald F., Meng, Guangxun

Journal:

Year:

2016

Language:

english

File:

PDF, 1.44 MB

english, 2016

49

Joining forces: First application of a rapamycin-induced dimerizable CRE system (DiCre) for conditional null mutant analysis in Leishmania

Späth, Gerald F., Clos, Joachim

Journal:

Molecular Microbiology

Year:

2016

Language:

english

File:

PDF, 752 KB

english, 2016

50

Phenotypic Characterization of a Leishmania donovani Cyclophyilin 40 Null Mutant

Wai-Lok, Yau, Lambertz, Ulrike, Colineau, Lucie, Pescher, Pascale, MacDonald, Andrea, Zander, Dorothea, Retzlaff, Silke, Eick, Julia, Reiner, Neil E., Clos, Joachim, Späth, Gerald F.

Journal:

Journal of Eukaryotic Microbiology

Year:

2016

Language:

english

File:

PDF, 1.00 MB

english, 2016

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